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Long term treatment and disease severity change brain responses to levodopa in Parkinson's disease

Objectives: Degeneration of nigrostriatal neurons and subsequent striatal dopamine deficiency produce many of the symptoms of Parkinson disease (PD). Initially restoration of striatal dopamine with oral levodopa provides substantial benefit, but with long term treatment and disease progression, levo...

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Detalhes bibliográficos
Main Authors: Hershey, T, Black, K, Carl, J, McGee-Minnich, L, Snyder, A, Perlmutter, J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1738560/
https://ncbi.nlm.nih.gov/pubmed/12810765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.74.7.844
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