A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences.

HLA-B27 molecules expressed on the T2 mutant cell line do not have peptides. Such empty HLA-B27 molecules were not recognized by an HLA-B27-restricted cytotoxic T-lymphocyte (CTL) clone (auto-1) derived from synovial fluid. To test for peptide dependency of the clone, B27-T2 cells were incubated wit...

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Autores principales: Huang, F, Hermann, E, Wang, J, Cheng, X K, Tsai, W C, Wen, J, Kuipers, J G, Kellner, H, Ackermann, B, Roth, G, Williams, K M, Yu, D K, Raybourne, R B
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC173736/
https://ncbi.nlm.nih.gov/pubmed/8557329
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