Clinical trials of multiple sclerosis monitored with enhanced MRI: new sample size calculations based on large data sets

OBJECTIVE—A new parametric simulation procedure based on the negative binomial (NB) model was used to evaluate the sample sizes needed to achieve optimal statistical powers for parallel groups (with (PGB) and without (PG) a baseline correction scan). It was also used for baseline versus treatment (B...

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Detalhes bibliográficos
Main Authors: Sormani, M, Miller, D, Comi, G, Barkhof, F, Rovaris, M, Bruzzi, P, Filippi, M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2001
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1737302/
https://ncbi.nlm.nih.gov/pubmed/11254773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.70.4.494
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