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Disability outcome measures in therapeutic trials of relapsing-remitting multiple sclerosis: effects of heterogeneity of disease course in placebo cohorts

OBJECTIVES—Recent phase III clinical trials of immunomodulatory therapies in relapsing-remitting multiple sclerosis have shown significant benefits of active treatment on relapse related end points, but effects on disability outcomes have been inconsistent. These apparent discrepancies could be due...

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Detalhes bibliográficos
Main Authors: Liu, C., Blumhardt, L.
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1736854/
https://ncbi.nlm.nih.gov/pubmed/10727480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.68.4.450
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