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Genomic duplication in Dyggve Melchior Clausen syndrome, a novel mutation mechanism in an autosomal recessive disorder

Background: Dyggve Melchior Clausen syndrome (DMC) is a severe autosomal recessive skeletal dysplasia associated with mental retardation. Direct sequencing of genomic DNA has identified causative mutations in the gene Dymeclin (chromosome 18q12–21), with the majority predicting the generation of a t...

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Detalhes bibliográficos
Main Authors: Kinning, E, Tufarelli, C, Winship, W, Aldred, M, Trembath, R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735964/
https://ncbi.nlm.nih.gov/pubmed/16326827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.033829
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