Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

Background: Mutations in the E-cadherin (CDH1) gene are a well documented cause of hereditary diffuse gastric cancer (HDGC). Development of evidence based guidelines for CDH1 screening for HDGC have been complicated by its rarity, variable penetrance, and lack of founder mutations. Methods: Forty th...

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Main Authors: Brooks-Wilson, A, Kaurah, P, Suriano, G, Leach, S, Senz, J, Grehan, N, Butterfield, Y, Jeyes, J, Schinas, J, Bacani, J, Kelsey, M, Ferreira, P, MacGillivray, B, MacLeod, P, Micek, M, Ford, J, Foulkes, W, Australie, K, Greenberg, C, LaPointe, M, Gilpin, C, Nikkel, S, Gilchrist, D, Hughes, R, Jackson, C, Monaghan, K, Oliveira, M, Seruca, R, Gallinger, S, Caldas, C, Huntsman, D
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Group 2004
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735838/
https://ncbi.nlm.nih.gov/pubmed/15235021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.018275
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