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β(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome

Smith-Magenis syndrome (SMS) is a clinically recognisable contiguous gene syndrome ascribed to interstitial deletions of chromosome 17p11.2. Patients have a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Serum melatonin levels and day-night be...

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Autori principali: De Leersnyder, H., de Blois, M.-C., Vekemans, M., Sidi, D., Villain, E., Kindermans, C., Munnich, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734944/
https://ncbi.nlm.nih.gov/pubmed/11546826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.9.586
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