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Two hits revisited again

INTRODUCTION AND METHODS—Since the concept of the "two hit hypothesis" was introduced over 20 years ago, a wealth of genetic data has accumulated on the mutations found at tumour suppressor loci. Perhaps surprisingly, these data conceal large gaps in our knowledge which genetic and functio...

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Detalhes bibliográficos
Main Authors: Tomlinson, I, Roylance, R, Houlston, R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734812/
https://ncbi.nlm.nih.gov/pubmed/11158170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.2.81
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