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Polymorphisms in PTEN in breast cancer families

Germline mutations in PTEN are the underlying genetic defect in Cowden disease, which is associated with a lifetime risk of 25-50% of developing breast cancer. To investigate the role of PTEN in inherited breast cancer in the absence of manifestations of Cowden disease, we screened 177 unrelated sub...

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Detalhes bibliográficos
Main Authors: Carroll, B., Couch, F., Rebbeck, T., Weber, B.
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734307/
https://ncbi.nlm.nih.gov/pubmed/10051004
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