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Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

Aim—To investigate whether mutations in the STK11/LKB1 gene and genes implicated in the colorectal adenoma–carcinoma sequence are involved in Peutz-Jeghers syndrome (PJS) related tumorigenesis. Methods—Thirty nine polyps and five carcinomas from 17 patients (from 13 families) with PJS were analysed...

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Detalhes bibliográficos
Main Authors: Entius, M, Keller, J, Westerman, A, van Rees, B P, van Velthuysen, M-L F, de Goeij, A F P M, Wilson, J, Giardiello, F, Offerhaus, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1731344/
https://ncbi.nlm.nih.gov/pubmed/11215281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jcp.54.2.126
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