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Immunization with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague.

An attenuated Salmonella typhimurium strain which expressed the F1 capsular antigen of Yersinia pestis was constructed by transformation of S. typhimurium SL3261 with plasmid pFGAL2a, a derivative of pUC18 which contained the caf1 gene without the leader sequence. The recombinant was used to vaccina...

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Udgivet i:Infect Immun
Principais autores: Oyston, P C, Williamson, E D, Leary, S E, Eley, S M, Griffin, K F, Titball, R W
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173032/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7822022/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.2.563-568.1995
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