Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors

Mice deficient in the hematopoietic cell-specific adapter protein SLP-76 demonstrate a failure of T cell development and fetal hemorrhage. Although SLP-76-deficient platelets manifest defective collagen receptor signaling, this alone may not explain the observed bleeding diathesis. Because αIIbβ3, t...

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Autori principali: Judd, Barbi A., Myung, Peggy S., Leng, Lijun, Obergfell, Achim, Pear, Warren S., Shattil, Sanford J., Koretzky, Gary A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC17293/
https://ncbi.nlm.nih.gov/pubmed/11050236
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