In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug.

WIN 54954 (5-[5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl]-3- methylisoxazole) is a new member of the class of broad-spectrum antipicornavirus compounds known to bind in a hydrophobic pocket within virion capsid protein VP1. In plaque reduction assays, WIN 54954 reduced plaque formation...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Woods, M G, Diana, G D, Rogge, M C, Otto, M J, Dutko, F J, McKinlay, M A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172823/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2559655/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.12.2069
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