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New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.

Seventeen clinical isolates of Staphylococcus aureus (from the United States and Europe) selected for low (borderline)-level methicillin resistance (MIC of methicillin, 2 to 4 micrograms/ml; MIC of oxacillin, 0.5 to 8 micrograms/ml) were examined for their mechanisms of resistance. Five strains were...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Tomasz, A, Drugeon, H B, de Lencastre, H M, Jabes, D, McDougall, L, Bille, J
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172779/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2610497/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.11.1869
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