Herpes Simplex Virus Ribonucleotide Reductase Mutants Are Hypersensitive to Acyclovir

Eitemau Tebyg

• Herpes Simplex Virus Ribonucleotide Reductase Mutants Are Hypersensitive to Acyclovir
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• Topical treatment of infection with acyclovir-resistant mucocutaneous herpes simplex virus with the ribonucleotide reductase inhibitor 348U87 in combination with acyclovir.
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• Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.
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