The complex ATP–Fe(2+) serves as a specific affinity cleavage reagent in ATP-Mg(2+) sites of Na,K-ATPase: Altered ligation of Fe(2+) (Mg(2+)) ions accompanies the E(1)P→E(2)P conformational change
In the presence of ascorbate/H(2)O(2), ATP–Fe(2+) or AMP-PNP–Fe(2+) complexes act as affinity cleavage reagents, mediating selective cleavage of the alpha subunit of Na,K-ATPase at high affinity ATP–Mg(2+) sites. The cleavages reveal contact points of Fe(2+) or Mg(2+) ions. In E(1) and E(1)Na confor...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11035801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220332897 |
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