Mesalazine (5-aminosalicylic acid) induced chronic hepatitis

BACKGROUND—Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active...

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Bibliographic Details
Main Authors: Deltenre, P, Berson, A, Marcellin, P, Degott, C, Biour, M, Pessayre, D
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1727547/
https://ncbi.nlm.nih.gov/pubmed/10323894
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