Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.

We studied the pharmacokinetics and in vivo antifungal action of SCH39304, a new antifungal azole compound, in rabbits. It crossed the blood-cerebrospinal fluid barrier in the presence or absence of meningeal inflammation, reaching approximately 60% of the simultaneous concentrations in serum. In th...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Perfect, J R, Wright, K A, Hobbs, M M, Durack, D T
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1989
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556078/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.10.1735
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