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Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein

Alternate splicing, leading to the insertion of the tripeptide KTS in the linker between the third and fourth C(2)H(2) zinc fingers, changes both the DNA-binding function and the subnuclear localization of the Wilms' tumor suppressor protein (WT1). We have used NMR relaxation experiments to det...

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Detalhes bibliográficos
Main Authors: Laity, John H., Dyson, H. Jane, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17272/
https://ncbi.nlm.nih.gov/pubmed/11050227
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