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Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine.

The replication of human immunodeficiency virus in vitro is inhibited by some acyclic adenosine derivatives, such as 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], as well as by 3'-azido-3'-deoxythymidine (AZT). In a human...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Smith, M S, Brian, E L, De Clercq, E, Pagano, J S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172687/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2479334/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.9.1482
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