Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors
Improperly folded membrane proteins are retained in the endoplasmic reticulum and then diverted to a degradative pathway by a network of molecular chaperones and intracellular proteases. Here we report that mutant insulin proreceptors (Pro(62)) retained in the early secretory pathway undergo proteol...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11050224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.22.11905 |
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