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Simulation of human serum pharmacokinetics of ticarcillin-clavulanic acid and ceftazidime in rabbits, and efficacy against experimental Klebsiella pneumoniae meningitis.

The penetration into cerebrospinal fluid (CSF) and efficacy of ticarcillin-clavulanic acid, ticarcillin alone, and ceftazidime were compared in rabbits with experimentally induced Klebsiella pneumoniae meningitis. The compounds were administered to simulate in rabbit plasma the concentration-versus-...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Mizen, L, Woodnutt, G, Kernutt, I, Catherall, E J
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 1989
Soggetti:
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172516/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2665641/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.5.693
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