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Clinical features of a novel TIMP-3 mutation causing Sorsby's fundus dystrophy: implications for disease mechanism

AIMS—To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3).
METHODS—Three members of the same family were seen with a history of nyctalopia and visual loss due to maculopathy. Clinical feature...

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Autors principals: Clarke, M., Mitchell, K., Goodship, J., McDonnell, S., Barker, M., Griffiths, I., McKie, N.
Format: Artigo
Idioma:Inglês
Publicat: 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1723822/
https://ncbi.nlm.nih.gov/pubmed/11734514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bjo.85.12.1429
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