Inhibition of Escherichia coli growth and diaminopimelic acid epimerase by 3-chlorodiaminopimelic acid.

The diaminopimelic acid (DAP) analog, 3-chloro-DAP, was synthesized and tested as the racemic acid for antibacterial activity and for inhibition of DAP epimerase. 3-Chloro-DAP was a potent inhibitor of DAP epimerase purified from Escherichia coli (Ki = 200 nM), and it is argued that 3-chloro-DAP is...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Baumann, R J, Bohme, E H, Wiseman, J S, Vaal, M, Nichols, J S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172362/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3056252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.8.1119
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