Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, th...

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Publikašuvnnas:	Antimicrob Agents Chemother
Váldodahkkit:	Karlsson, A, Harmenberg, J
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 1988
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2847642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.7.1100
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