Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.

We evaluated the effects of natural purine and pyrimidine nucleosides on protection from or reversal of 3'-azido-3'-deoxythymidine (AZT) cytotoxicity in human bone marrow progenitor cells by using clonogenic assays. The selectivity of the "protection" or "rescue" agents...

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Main Authors: Sommadossi, J P, Carlisle, R, Schinazi, R F, Zhou, Z
Formato: Artigo
Idioma:Inglês
Publicado: 1988
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC172332/
https://ncbi.nlm.nih.gov/pubmed/3190201
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