Effects of cyclophosphamide and a metabolite, acrolein, on Naegleria fowleri in vitro and in vivo.

Mice challenged intranasally with Naegleria fowleri died of primary amoebic meningoencephalitis. Mice given 30 mg of cyclophosphamide per kg of body weight daily for 10 days starting 2 days before challenge were protected. Neither cyclophosphamide nor serum from cyclophosphamide-treated mice inhibit...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Zhang, L, Marciano-Cabral, F, Bradley, S G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172325/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3190198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.7.962
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