γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E(2) (PGE(2)) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease. Here we report that γ-tocopherol (γT) reduced PGE(2) synthesis in both lipopolysaccharide (LPS)-stimulated RAW264.7 mac...

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Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Jiang, Qing, Elson-Schwab, Ilan, Courtemanche, Chantal, Ames, Bruce N.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2000
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17228/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.200357097
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