IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44(hi)CD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8αα′...

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Main Authors: Marks-Konczalik, Joanna, Dubois, Sigrid, Losi, Jacqueline M., Sabzevari, Helen, Yamada, Nobuo, Feigenbaum, Lionel, Waldmann, Thomas A., Tagaya, Yutaka
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17219/
https://ncbi.nlm.nih.gov/pubmed/11016962
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