Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F).

In this study, local and systemic tolerance and pharmacokinetics of trospectomycin sulfate in human beings were evaluated for the first time. Trospectomycin sulfate (U-63,366F; trospectomycin) or sterile saline was administered to 96 healthy male volunteers in doses ranging from 0.25 ml (75 mg) to 3...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Novak, E, Paxton, L M, Bye, A, Patel, R, Zurenko, G E, Francom, S F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2150907/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.12.2342
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