Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system.

GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Silley, P, Griffiths, J W, Monsey, D, Harris, A M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2285295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.9.1806
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