Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis.

The efficacies of SCH39304 (SCH) and fluconazole (FLU) were tested in a murine model of coccidioidomycosis. CD-1 mice were infected with Coccidioides immitis and dosed with SCH at 2, 10, 25, or 50 mg/kg per day or FLU at 10 or 100 mg/kg per day. Survival was enhanced (P less than 0.001) by both drug...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Clemons, K V, Hanson, L H, Perlman, A M, Stevens, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171724/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2360832/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.5.928
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