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Role of the NEDD8 Modification of Cul2 in the Sequential Activation of ECV Complex

ECV is an E3 ubiquitin ligase complex, which is composed of elongins B and C, Rbx1, Cul2, and the substrate-conferring von Hippel-Lindau (VHL) tumorsuppressor protein that targets the catalytic α subunit of hypoxia-inducible factor (HIF) for oxygen-dependent ubiquitin-mediated destruction. Mutations...

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Autori principali: Sufan, Roxana I, Ohh, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716018/
https://ncbi.nlm.nih.gov/pubmed/17132228
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