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True and false positive peaks in genomewide scans: applications of length-biased sampling to linkage mapping.

Disease-susceptibility loci are now being mapped via genomewide scans in which a linkage statistic is computed at each of a large number of markers. Such disease-susceptibility loci may be identified via a peak in the test statistic when the latter is plotted against the genetic map. In this paper w...

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Main Authors: Terwilliger, J D, Shannon, W D, Lathrop, G M, Nolan, J P, Goldin, L R, Chase, G A, Weeks, D E
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1715919/
https://ncbi.nlm.nih.gov/pubmed/9311749
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