Outer membrane permeability and beta-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents.

Some enteric bacteria, such as Enterobacter cloacae, can develop high-level resistance to broad-spectrum cephalosporins by overproducing their chromosomally encoded type I beta-lactamases. This is because these agents are hydrolyzed rapidly at pharmacologically relevant, low (0.1 to 1 microM), conce...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Nikaido, H, Liu, W, Rosenberg, E Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171583/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2109581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.2.337
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