Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms.

It has been assumed that penicillin (and also other cell wall inhibitors) kill pneumococci predominantly by triggering their major autolytic enzyme (an N-acetylmuramoyl-L-alanine amidase; referred to as amidase), resulting in massive cell wall degradation. Three types of experiments suggest that onl...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Moreillon, P, Markiewicz, Z, Nachman, S, Tomasz, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171516/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1691615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.1.33
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