Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo

Cripto, a cell surface–associated protein belonging to the EGF-CFC family of growth factor–like molecules, is overexpressed in many human solid tumors, including 70–80% of breast and colon tumors, yet how it promotes cell transformation is unclear. During embryogenesis, Cripto complexes with Alk4 vi...

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Detalhes bibliográficos
Main Authors: Adkins, Heather B., Bianco, Caterina, Schiffer, Susan G., Rayhorn, Paul, Zafari, Mohammad, Cheung, Anne E., Orozco, Olivia, Olson, Dian, De Luca, Antonella, Chen, Ling Ling, Miatkowski, Konrad, Benjamin, Chris, Normanno, Nicola, Williams, Kevin P., Jarpe, Matthew, LePage, Doreen, Salomon, David, Sanicola, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC171388/
https://ncbi.nlm.nih.gov/pubmed/12925698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317788
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