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Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA.

As reported by Jamieson and Subak-Sharpe (J. Gen. Virol. 31:303-313, 1976), exogenous deoxycytidine is very poorly incorporated into herpes simplex virus DNA. Here it is shown that this incorporation was dramatically increased in the presence of tetrahydrouridine (THU), a specific inhibitor of cytid...

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Published in:J Virol
Main Authors: North, T W, Mathews, C K
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1981
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171096/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6262539/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.37.3.987-993.1981
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