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A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition

The molecular events that lead to the onset of labor in humans and in other mammalian species remain unclear. We propose that a decline in coactivators containing histone acetylase activity in myometrium may contribute to the onset of labor by impairing the function of the progesterone–progesterone...

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Hlavní autoři: Condon, Jennifer C., Jeyasuria, Pancharatnam, Faust, Julie M., Wilson, James W., Mendelson, Carole R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC170950/
https://ncbi.nlm.nih.gov/pubmed/12886011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633616100
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