An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

The t(8;21)(q22;q22) translocation, occurring in 40% of patients with acute myeloid leukemia (AML) of the FAB-M2 subtype (AML with maturation), results in expression of the RUNX1-CBF2T1 [AML1-ETO (AE)] fusion oncogene. AML/ETO may contribute to leukemogenesis by interacting with nuclear corepressor...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Grisolano, Jay L., O'Neal, Julie, Cain, Jennifer, Tomasson, Michael H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC170948/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12881486/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1531730100
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