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The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics
An extension of the “squirming test” is described which makes the method specific for nonnarcotic analgesics. The intraperitoneal injection of acetic acid causes squirming and an increase in capillary permeability that is measured by direct estimation of plasma-bound dye (Pontamine Sky Blue) which h...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1964
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1703970/ https://ncbi.nlm.nih.gov/pubmed/14190460 |
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