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Influence of pH on aggregation and protein binding of barbituric acid and amylobarbitone
1. Cryoscopic methods indicated that barbituric acid exists in aqueous solution as a monomer. Amylobarbitone is a monomer at pH 8, but appears to be polymerized at pH 2. The size of the oligomers increases with drug concentration. 2. Using a non-equilibrium dialysis technique supportive evidence for...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1971
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702740/ https://ncbi.nlm.nih.gov/pubmed/5547763 |
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