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The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system

The genetic lesion in the quakingviable (qk(v)) mutant mice is a deletion 5′ to the qkI gene, resulting in severe hypomyelination. qkI produces several QKI protein isoforms via alternative splicing of the C-terminal coding exons. In the qk(v)/qk(v) brain, immunostaining of QKI proteins is diminished...

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Detalhes bibliográficos
Main Authors: Lu, Zifan, Zhang, Youyi, Ku, Li, Wang, Houping, Ahmadian, Amir, Feng, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC169897/
https://ncbi.nlm.nih.gov/pubmed/12888522
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