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The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system
The genetic lesion in the quakingviable (qk(v)) mutant mice is a deletion 5′ to the qkI gene, resulting in severe hypomyelination. qkI produces several QKI protein isoforms via alternative splicing of the C-terminal coding exons. In the qk(v)/qk(v) brain, immunostaining of QKI proteins is diminished...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2003
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC169897/ https://ncbi.nlm.nih.gov/pubmed/12888522 |
| Etiketak: |
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