JAB1 Determines the Response of Rheumatoid Arthritis Synovial Fibroblasts to Tumor Necrosis Factor-α

Fibroblast-like synoviocytes (FLSs) of patients with rheumatoid arthritis (RA FLSs) exhibit prosurvival, rather than apoptotic, response to tumor necrosis factor (TNF)-α stimulation. Here, we show that JAB1 is a critical regulator of the TNF-α-mediated anti-apo-ptosis pathways in RA FLSs. We found t...

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Hlavní autoři: Wang, Jianhua, Li, Chuanyu, Liu, Yuelong, Mei, Wan, Yu, Shaohua, Liu, Cunren, Zhang, Liming, Cao, Xu, Kimberly, Robert P., Grizzle, William, Zhang, Huang-Ge
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2006
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698810/
https://ncbi.nlm.nih.gov/pubmed/16936264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051161
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