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Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. The enzymatic activity of PRS is regulated by phosphate ions, divalent metal cations and ADP. In the present s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698673/ https://ncbi.nlm.nih.gov/pubmed/16939420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061066 |
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