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A Chromosomal Rearrangement Hotspot Can Be Identified from Population Genetic Variation and Is Coincident with a Hotspot for Allelic Recombination

Insights into the origins of structural variation and the mutational mechanisms underlying genomic disorders would be greatly improved by a genomewide map of hotspots of nonallelic homologous recombination (NAHR). Moreover, our understanding of sequence variation within the duplicated sequences that...

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Bibliografiske detaljer
Main Authors: Lindsay, Sarah J., Khajavi, Mehrdad, Lupski, James R., Hurles, Matthew E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698570/
https://ncbi.nlm.nih.gov/pubmed/17033965
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