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Mutation-Positive and Mutation-Negative Patients with Cowden and Bannayan-Riley-Ruvalcaba Syndromes Associated with Distinct 10q Haplotypes

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a tumor-suppressor phosphatase frequently mutated in both sporadic and heritable forms of human cancer. Germline mutations are associated with a number of heritable cancer syndromes that are jointly referred to as the “PTEN hamar...

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Autores principales: Pezzolesi, Marcus G., Li, Yan, Zhou, Xiao-Ping, Pilarski, Robert, Shen, Lei, Eng, Charis
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Human Genetics 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698555/
https://ncbi.nlm.nih.gov/pubmed/17033968
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