Immunogenicity of a Yersinia pestis Vaccine Antigen Monomerized by Circular Permutation

Caf1, a chaperone-usher protein from Yersinia pestis, is a major protective antigen in the development of subunit vaccines against plague. However, recombinant Caf1 forms polymers of indeterminate size. We report the conversion of Caf1 from a polymer to a monomer by circular permutation of the gene....

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Autori principali: Chalton, David A., Musson, Julie A., Flick-Smith, Helen, Walker, Nicola, McGregor, Alistair, Lamb, Heather K., Williamson, E. Diane, Miller, Julie, Robinson, John H., Lakey, Jeremy H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698084/
https://ncbi.nlm.nih.gov/pubmed/16982834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00437-06
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