Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action

In contrast with most inhalational anesthetics, the anesthetic gases xenon (Xe) and nitrous oxide (N(2)O) act by blocking the N-methyl-d-aspartate (NMDA) receptor. Using x-ray crystallography, we examined the binding characteristics of these two gases on two soluble proteins as structural models: ur...

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Main Authors: Colloc'h, Nathalie, Sopkova-de Oliveira Santos, Jana, Retailleau, Pascal, Vivarès, Denis, Bonneté, Françoise, Langlois d'Estainto, Béatrice, Gallois, Bernard, Brisson, Alain, Risso, Jean-Jacques, Lemaire, Marc, Prangé, Thierry, Abraini, Jacques H.
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2007
Assuntos:
Proteins
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697869/
https://ncbi.nlm.nih.gov/pubmed/17028130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.093807
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