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Spontaneous Recovery of Pathogenicity by Leishmania major hsp100(−)(/)(−) Alters the Immune Response in Mice
By using repeated mouse infection cycles, we obtained an escape variant with restored infectivity and pathogenicity that originated from a single, noninfectious hsp100(−)(/)(−) gene (formerly known as ΔclpB) replacement clone of Leishmania major, the causative agent of cutaneous leishmaniasis. This...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1695515/ https://ncbi.nlm.nih.gov/pubmed/17057085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00773-05 |
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